Motilium alternatives: what to try instead of domperidone

Motilium (domperidone) helps with nausea and bloating, but safety concerns—especially heart rhythm risks—have pushed doctors and regulators to look for other options. If you're worried about domperidone or can't take it, here are practical alternatives you can discuss with your clinician, plus simple steps you can try right now.

Prescription drug options

Metoclopramide is a common alternative. It speeds stomach emptying and helps with nausea, but it can cause movement side effects if used long-term, so doctors usually limit the dose and duration. Ondansetron is another choice—it's a 5-HT3 blocker often used for severe nausea from chemo or surgery and works well for many people. Prochlorperazine and promethazine are older antiemetics that control nausea but can make you drowsy.

For gastroparesis (delayed stomach emptying), some clinicians use low-dose erythromycin short-term because it acts like a prokinetic. Each drug has trade-offs: effectiveness, side effects, and interactions. If you have heart disease or take other medicines that affect the heart rhythm, your doctor will pick an option that avoids QT prolongation.

OTC, herbal, and lifestyle fixes

If your nausea is mild, try over-the-counter steps first. Meclizine helps with motion sickness and inner-ear related nausea. Ginger—in tea, capsules, or candied form—can ease mild nausea and is low risk for most people. Small, frequent bland meals, staying hydrated, and avoiding greasy or spicy foods often cut symptoms quickly. Acupressure at the P6 point (wrist) is simple and has helped many people reduce nausea without drugs.

Sleep, slow breathing, and avoiding strong smells also help. If you’re dealing with reflux-related nausea, treating reflux with antacids or an H2 blocker like famotidine (talk to your doctor first) can be part of the solution.

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Two quick safety rules: 1) Always tell your prescriber about every medicine and supplement you take—some combos raise heart risk. 2) If a drug causes sudden chest pain, fainting, or severe palpitations, seek emergency care right away.

If you’re uncertain which alternative fits your situation, ask your doctor for a short trial under supervision. For chronic nausea, a combo approach—diet changes, a safer antiemetic, and treating underlying causes—usually works best. Need deeper reading? We have articles on related topics like safety reviews, buying meds online, and specific drug alternatives to help you decide.