Lurasidone (Latuda): A Practical Guide for Patients

Lurasidone, sold commonly as Latuda, is a prescription antipsychotic used to treat schizophrenia and bipolar depression in adults and some adolescents. If you or someone you care for has been offered lurasidone, this page gives straightforward facts you can use when talking with your prescriber or pharmacist.

How lurasidone works and who it helps

Lurasidone affects dopamine and serotonin receptors in the brain. That helps reduce psychotic symptoms like delusions and hallucinations and can improve mood during a bipolar depressive episode. Doctors typically prescribe it for adults with schizophrenia or bipolar depression; it’s also approved for some teens depending on the diagnosis and country.

Unlike some older antipsychotics, lurasidone tends to cause less weight gain and fewer metabolic problems for many people. But it can still cause movement-related side effects, so monitoring is important.

How to take lurasidone — simple rules

Take lurasidone exactly as your doctor tells you. A few practical points matter a lot:

- Take it once a day with food. You need about 350 calories with the dose for the medicine to absorb properly.

- Typical starting doses: for schizophrenia many adults start at 40 mg once daily (range 40–160 mg). For bipolar depression the usual range is 20–60 mg once daily. Your doctor will pick the right dose for you.

- Don’t stop suddenly without medical advice. Stopping quickly can cause withdrawal symptoms or return of symptoms.

Lurasidone is broken down by the liver enzyme CYP3A4. Strong inhibitors (like some antibiotics and antifungals) or inducers (like rifampin or some seizure drugs) change lurasidone levels. Always tell your doctor about other medicines, supplements, or herbal products you use.

Side effects and safety tips

Common side effects include drowsiness, nausea, restlessness (akathisia), and stiffness. Pay attention to new or worsening restlessness or trouble sitting still — those can be signs of movement side effects that need attention.

Less common but serious issues include severe movement disorders, signs of an allergic reaction, or sudden changes in mood or suicidal thoughts. If you notice those, contact your healthcare provider right away.

Avoid drinking alcohol while on lurasidone — it can increase drowsiness and other effects. Be cautious when driving until you know how the drug affects you. If you have liver problems, let your doctor know; dose changes or a different drug might be safer.

Before starting, discuss pregnancy plans, breastfeeding, and any heart conditions. Your doctor may recommend blood tests or checkups during the first weeks to monitor for side effects and response.

If you have questions about brand vs generic, cost, or how lurasidone fits with other treatments, ask your pharmacist or prescriber. Small, clear steps—take with food, watch for restlessness, and report major changes—make the medication safer and more effective for most people.